---

Factors Associated With Oxidative Stress in the Testes and the Mitigating Role of Antioxidants: A Review

Full Text PDF

---

Review Article

Author Details : Siva Kumar T, Neeraja P*

Volume : 1, Issue : 1, Year : 2019

Article Page : 6-12

https://doi.org/10.18231/j.ijrimcr.2019.002

Suggest article by email

Abstract

Present day’s reports have increased on relation to infertility of males associated with decreasing semen quality by the oxidative stress causing factors. Numerous external and internal factors were responsible for the ROS (reactive oxygen species) production, excessive ROS further effects on cellular antioxidant capacity in consequence leads to oxidative tension. The exogenous factors like, high testicular temperature, diabetes, Present life style and food habits, Declined testicular antioxidants, exposure of toxicants, exposure of radiation (X-ray) responsible for the imbalance production of hormones and antioxidants. However, under normal condition, the body has the ability to synthesize antioxidant defense enzymes for prohibiting the undesirable oxidative stress effects. But chronic exposure to environmental toxicants (endocrine disrupters, pesticides, xenobiotics) ionizing radiation and heat stress the body’s antioxidants cannot stabilize the free radicals for prevention of deleterious oxidative stress in the testis. The impaired antioxidant system is associated with declining levels of antioxidant enzymes, increased levels of stress markers and probably affects the hormonal mechanism. This leads to abnormal sperm production and testicular morphological changes occur, finally leading to infertility in males. Exogenous antioxidant therapy (zinc, selenium, vitamins, and plant related compounds) can chelate the oxidative stress reaction and play an important role in improving the body’s ability to fight against free radicals induced oxidative stress factors, and therefore betterment in the course of spermatogenesis.

Keywords: External factors, ROS, oxidative stress, antioxidant therapy, spermatogenesis.

How to cite : Siva Kumar T, Neeraja P, Factors Associated With Oxidative Stress in the Testes and the Mitigating Role of Antioxidants: A Review. Int J Recent Innov Med Clin Res 2019;1(1):6-12

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.