Introduction: A rare subtype of osteosarcoma, small cell osteosarcoma has received little research that has mainly focused on histological characteristics. In our center, there are only 2 patients who were definitely diagnosed as small cell osteosarcoma within 11 years. Here, we describe a unique incidence of small-cell osteosarcoma in a female patient between 17 and 35 that manifested in her right proximal tibia and hip.
Presentation of Case: We present two cases of small cell osteosarcoma of the tibia and hip in women aged 17 and 35 years. In this case the diagnosis hard to determine, so we need a spesific immunohiystochemistry examination to establish a definite diagnosis.
Conclusion: According to the research, which claims that small cell osteosarcoma is an uncommon variety and only makes up 1.3% of all instances of osteosarcoma, small cell osteosarcoma is a rare case. Establishing a diagnosis at our center is still difficult because it requires several examination modalities to reach a definite diagnosis. It's critical to distinguish this tumor from Ewing's sarcoma and other types of osteosarcoma in order to assess its occurrence, clinical characteristics, ideal treatment, and prognosis.
Keywords: Osteosarcoma, small cell variant.
