International Journal of Recent Innovations in Medicine and Clinical Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN:-
Online ISSN:-2582-1075
Original Article
Author Details :
Volume : 5, Issue : 1, Year : 2023
Article Page : 17-26
https://doi.org/10.18231/j.ijrimcr.2023.003
Abstract
Background: Abnormal Uterine Bleeding (AUB) is any uterine bleeding that is more than the normal volume (50-80 ml) or duration. It includes both organic and nonorganic causes. The PALM COEIN classification system helps us in understanding various etiological causes of AUB and can be used by clinicians and researchers for international comparisons. Increased risk of endometrial hyperplasia and endometrial carcinoma is more evident in perimenopausal and postmenopausal women with AUB. Histomorphological examination of endometrial biopsies and curetting is considered to be the gold standard in the diagnosis of its etiology. Many women with AUB undergo unwanted hysterectomy without a definitive diagnosis, so early diagnosis for cause of
AUB is crucial as various uterine pathologies can be picked up and timely treatment can improve patient quality of life.
Methods: A prospective study was conducted in department of Pathology, BPS GMC for Women, Khanpur Kalan over a period of 1 year. A total of 205 cases of AUB with a probable endometrial cause in women in perimenopausal and postmenopausal age group were included in the study.
Results: Out of all cases of AUB non organic contributes maximum 52% followed by organic cause (48%) in patients presenting with AUB. Dysfunctional uterine bleeding were most common (103 cases) as per clinical diagnosis followed by bleeding with pain in 34. Perimenopausal age group (80.9%) contributes maximum towards both nonorganic and organic cause (AUB) in 56.7% and 43.3% cases respectively followed by postmenopausal age group in 19.1% cases. Maximum incidence of AUB in multiparous (70.2%) followed by 28.3% cases of grand multiparous and least in nulliparous women (1.5%). Endometrial carcinoma is most commonly seen in grand multiparous in 72.7% cases where as endometrial hyperplasia and leiomyoma were commonly seen in multiparous women in 40.7% and 31.2% cases respectively. The most common presenting complaint was HMB; Heavy Menstrual Bleed (menorrhagia) (57.56%).
Conclusions: Endometrial sampling is now considered as first line diagnostic tool because of its diagnostic accuracy, safety, quickness and convenience. Histomorphological study of endometrium plays an important role in assisting in right treatment. The histopathological examination revealed significantly more cases of COEIN component of AUB.
Keywords: Abnormal Uterine Bleeding (AUB), Heavy Menstrual Bleed (HMB), Menorrhagia, Perimenopausal, Postmenopausal.
How to cite : Rathore R, Kundu P R, Siwach S, Agarwal D, Kulhariya A, Singh H, Parul*, Histomorphological Profile of Endometrium with Abnormal Uterine Bleeding in Perimenopausal and Postmenopausal Women. Int J Recent Innov Med Clin Res 2023;5(1):17-26
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