International Journal of Recent Innovations in Medicine and Clinical Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN:-
Online ISSN:-2582-1075
Short Communication
Author Details :
Volume : 6, Issue : 4, Year : 2024
Article Page : 134-136
https://doi.org/10.18231/j.ijrimcr.2024.065
Abstract
Epitranscriptomics, the study of RNA modifications such as N6-methyladenosine (m6A), has emerged as a pivotal field in cancer research. These chemical modifications influence gene expression, protein translation and cellular behavior, driving critical processes like tumor initiation, progression and metastasis. Furthermore, RNA modifications contribute to cancer stem cell plasticity, promoting survival and therapy resistance. Treatment resistance, a major obstacle in cancer therapy, is often driven by aberrant RNA modifications that affect the stability of coding and non-coding RNAs, leading to enhanced DNA repair, drug efflux and immune evasion. As a result, targeting RNA-modifying enzymes has gained attention as a novel therapeutic strategy. Inhibitors of "writers," "erasers" and "readers" of these modifications are currently being explored to restore sensitivity to conventional therapies. This commentary discusses the emerging role of RNA modifications in cancer progression and treatment resistance, highlighting the potential for novel therapeutic interventions in combatting drug-resistant cancers.
Keywords : Genetic techniques, Nanopore sequencing, Drug development, Machine learning, Cancer progression, Epitranscriptomics
How to cite : Nawal H, Epitranscriptomics in oncology: The double-edged role of RNA modifications in cancer and resistance. Int J Recent Innov Med Clin Res 2024;6(4):134-136
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